hPTK7/MC-38
CBPG0121
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產(chǎn)品描述
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| I. Background | |
| PTK7 是一種缺乏催化活性的受體蛋白酪氨酸激酶，隸屬于蛋白激酶家族，因最早在 結(jié)腸癌中被發(fā)現(xiàn)，故又被稱為 cck-4。作為 Wnt/β-catenin 和 Wnt/PCP 信號(hào)通路的常見(jiàn)參與 者，PTK7 對(duì)這兩種信號(hào)通路均有促進(jìn)或抑制作用。PTK7 能與相應(yīng)配體結(jié)合（即二聚化）、 并自身磷酸化激活下游一系列級(jí)聯(lián)傳遞并調(diào)控細(xì)胞增殖、分化及凋亡。 PTK7 基因存在組 織特異性，在多種腫瘤中表達(dá)水平升高，其高表達(dá)于胃癌、結(jié)直腸腫瘤、乳腺癌、卵巢癌 等。 而在子宮頸癌、脂肪肉瘤、血液腫瘤中 ，PTK7 呈現(xiàn)為低表達(dá)。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hPTK7 |
| Stability: | 32 passages |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+5 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data
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| V. In VIVO Data | |
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Index |
Content |
|
Animal |
C57BL/6J, 6weeks, female |
|
Implanted Position |
Subcutaneous (right lower flank region ) |
|
Injected Cell Numbers |
1×10^6/0.1ml |
|
Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hPTK7/MC38 Mean Body Weight ± SEM.
2. Tumor Size
Figure 3.hPTK7/MC38 Mean Tumor Volume ± SEM .
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
