AI-Edigene? EGFR p.L747_T751delinsP Reference Standard Plus
CBP10749
詢(xún) 價(jià)
索取COA
產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫(kù)
| Introduction | |
| Format | Genomic DNA |
| Description | EGFR E746_A750del results in the deletion of five amino acids in the kinase domain of the Egfr protein from amino acids 746 to 750. E746_A750del results in increased Egfr kinase activity, activation of p44/42 MAPK and AKT in cell culture, promotes tumor growth in xenograft models, and is transforming in cell culture. |
| Technical Data | |
| DNA Change | c.2239_2253delinsCCT |
| AA Change | p.L747_T751delinsP |
| Mutation type | Deletion - In frame |
| Zygosity | Heterozygous |
| Allelic Frequency | 50% |
| Transcript | ENST00000275493 |
| Cosmic ID | N/A |
| Chr position(GRCh37) | chr7:55242469-55242483 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
